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. 2022 Jun 27;14(8):e15418. doi: 10.15252/emmm.202115418

Figure EV1. Genetic maps of Transmorphic Phage/AAV, TPA and Adeno‐associated Virus/Phage, AAVP.

Figure EV1

  • A
    A schematic diagram of the TPA DNA encoding enhanced eGFP. TPA contains two origins of replication: pUC (high copy‐number, in yellow), which enables double‐stranded DNA replication in prokaryotic hosts, and f1 ori (phage origin of replication, in red), which enables single‐stranded DNA replication and packaging into the phage capsid.
  • B
    A schematic diagram of the chimeric genome of AAVP encoding eGFP. AAVP contains the full genomic sequence of filamentous bacteriophage, and a transgene cassette from AAV‐2 inserted in to an intergenomic region.