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. 2022 Jun 30;298(8):102213. doi: 10.1016/j.jbc.2022.102213

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

RNA-seq analysis identified 1,25(OH)₂D₃-induced classical 1,25(OH)₂D₃targets that mediate intestinal Ca absorption.A, schematic depicts intestinal compartments investigated for RNA-seq analysis along the crypt/villus and proximal/distal axis; B, basal and 1,25(OH)₂D₃ -mediated regulation of Vdr mRNA in the three intestinal compartments. C, a model for 1,25(OH)₂D₃-regulated transcellular intestinal calcium absorption where TRPV6 permits Ca entry, Calbindin D_9k (coded by S100g) buffers intracellular Ca, and PMCA1b (encoded by Atp2b1) facilitates ATP-dependent Ca extrusion from the cell. C-F, mRNA levels for Trpv6, S100g, and Atp2b1 as regulated by 1,25(OH)₂D₃ treatment (10 ng/g, 4 h) in the three intestinal compartments. In panels (B), (D), (E), and (F), data groups with different letter superscripts are significantly different from one another (p < 0.05, ANOVA followed by Tukey’s HSD). 1,25(OH)2D3, 1,25-dihydroxyvitamin D3.