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. 2022 Jul 25;29(9):103393. doi: 10.1016/j.sjbs.2022.103393

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — H&E stained liver tissue sections from control (A), OS (B), OS + CMF (C), OS + CMF + LDS (D), OS + CMF + HDS (E) rats. Histology of osteosarcoma rats (OS group) displaying ballooning degeneration of hepatocytes (indicated by triangle), sinusoid congestion (indicated by hallow arrow) and inflammation (arrow) as against normal histology seen in the control group. Tissue sections from OS + CMF groups showed regeneration of hepatocytes but lesser sinusoid congestion and moderate inflammation, Rats from OS + CMF + LDS group demonstrated reduced degeneration, no sinusoid congestion and mild inflammation in liver tissues, whereas near normal histology was observed in tissue sections from OS + CMF + HDS group rats.