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. 2022 Jul 25;29(9):103393. doi: 10.1016/j.sjbs.2022.103393

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 2 — H&E stained kidney tissue sections from control (A), OS (B), OS + CMF (C), OS + CMF + LDS (D), OS + CMF + HDS (E) rats. Histology of osteosarcoma rats (OS group) displaying shrinking of glomerular tuft (arrow) and tubular atrophy (hallow arrow) as compared to normal histology seen in the control group. Tissue sections from OS + CMF groups showed slightly congested glomeruli and moderate tubular atrophy. Rats from OS + CMF + LDS group demonstrated no glomeruli congestion and mild tubular atrophy, whereas no apparent histological changes were noted in kidney tissue sections from OS + CMF + HDS group rats.