Table 3. Multivariable adjusted odds ratios for gallstone by disease subtypes*.
| Characteristics | Overall | GB stones | IHD stones | EHD stones | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cases (%) | OR (95% CI) | Cases (%) | OR (95% CI) | Cases (%) | OR (95% CI) | Cases (‱) | OR (95% CI) | ||||
| Age, years | |||||||||||
| <30 | 45,614 (2.1) | Ref | 22,455 (1.0) | Ref | 23,356 (1.1) | Ref | 46 (0.2) | Ref | |||
| 30–50 | 175,090 (4.3) | 1.97 (1.95–2.00) | 129,567 (3.2) | 2.83 (2.79–2.87) | 46,614 (1.1) | 1.14 (1.12–1.16) | 258 (0.6) | 2.88 (2.10–3.96) | |||
| 50–70 | 166,089 (7.4) | 3.39 (3.36–3.43) | 141,343 (6.4) | 5.49 (5.42–5.57) | 25,907 (1.2) | 1.21 (1.19–1.23) | 476 (2.1) | 8.1 (5.93–11.06) | |||
| ≥70 | 29,958 (12.2) | 6.07 (5.98–6.16) | 26,825 (11.4) | 10.51 (10.32–10.70) | 3,361 (1.4) | 1.42 (1.37–1.47) | 152 (6.2) | 19.28 (13.70–27.12) | |||
| Gender | |||||||||||
| Women | 208,979 (5.1) | Ref | 163,163 (4.0) | Ref | 47,075 (1.1) | Ref | 568 (1.4) | Ref | |||
| Men | 207,772 (4.5) | 0.83 (0.82–0.83) | 157,027 (3.4) | 0.77 (0.76–0.77) | 52,163 (1.1) | 1.10 (1.09–1.11) | 364 (0.8) | 0.67 (0.58–0.76) | |||
| BMI, kg/m2 | |||||||||||
| ≤18.50 | 10,987 (2.7) | Ref | 5,776 (1.4) | Ref | 5,272 (1.3) | Ref | 37 (0.9) | Ref | |||
| 18.5–24.99 | 214,212 (4.2) | 1.23 (1.21–1.26) | 151,047 (3.0) | 1.50 (1.46–1.54) | 64,645 (1.3) | 0.96 (0.93–0.99) | 565 (1.1) | 0.75 (0.54–1.05) | |||
| 25.0–29.99 | 159,759 (5.7) | 1.52 (1.49–1.55) | 134,210 (4.9) | 2.14 (2.08–2.20) | 26,535 (1.0) | 0.72 (0.69–0.74) | 295 (1.1) | 0.57 (0.40–0.81) | |||
| ≥30 | 31,793 (6.3) | 1.77 (1.73–1.81) | 29,157 (5.9) | 2.77 (2.69–2.85) | 2,786 (0.6) | 0.43 (0.41–0.45) | 35 (0.7) | 0.39 (0.24–0.62) | |||
| Fasting glucose, mmol/L | |||||||||||
| <7 | 384,599 (4.6) | Ref | 290,841 (3.5) | Ref | 96,246 (1.1) | Ref | 853 (1.0) | Ref | |||
| ≥7 | 32,152 (8.6) | 1.31 (1.30–1.33) | 29,349 (8.1) | 1.41 (1.39–1.43) | 2,992 (0.8) | 0.77 (0.74–0.79) | 79 (2.1) | 1.14 (0.90–1.44) | |||
| Total triglyceride, mmol/L | |||||||||||
| <2.27 | 344,889 (4.6) | Ref | 258,737 (3.5) | Ref | 88,473 (1.2) | Ref | 798 (1.1) | Ref | |||
| ≥2.27 | 71,862 (5.5) | 1.02 (1.01–1.02) | 61,453 (4.8) | 1.09 (1.08–1.10) | 10,765 (0.8) | 0.77 (0.76–0.79) | 134 (1.0) | 0.89 (0.74–1.07) | |||
| Previous cholecystectomy | |||||||||||
| No | 414,797 (4.8) | Ref | 319,817 (3.7) | – | 97,870 (1.1) | Ref | 689 (0.8) | Ref | |||
| Yes | 1,954 (2.0) | 0.27 (0.25–0.28) | 373 (100.0) | – | 1,368 (1.4) | 1.27 (1.21–1.34) | 243 (24.9) | 17.98 (15.42–20.97) | |||
*, logistic model was used by adjusting age (<30, 30–50, 50–70, ≥70 years old), gender (men, women), BMI (≤18.50, 18.5–24.99, 25.0–29.99, ≥30 kg/m2), fasting glucose (<7, ≥7 mmol/L), total triglyceride (<2.27, ≥2.27 mmol/L), and previous cholecystectomy (no, yes). BMI, body mass index; OR, odds ratio; GB, gall bladder; IHD, intrahepatic bile duct.