Table 4. In vivo anti-cancer effect of Neem (Azadirachta indica) on PCa.

Type of study	Cell line	Type of extract	Concentration	Dosage	Effect	Mechanism	References
In vivo	TRAMP	Nimbolide	3 mg/kg	5 times/week for 6–12 weeks	Reduced tumor growth and metastasis	Inhibition of STAT3 phosphorylation, decrease in Ki-67	(8)
In vivo	C4-2B and PC-3M-luc2 in nude mice	Ethanolic Neem leaf extract	100, 200 mg/kg	6 times/week for 8–11 weeks	Inhibited tumor growth	Promotion of hyalinization and apoptosis	(12)
In vivo	LNCaP-luc2 xenograft in nude mice	SENL	100, 200 mg/kg	6 times/week for 9 weeks	Reduced tumor growth	Promotion of hyalinization and apoptosis	(13)

PCa, prostate cancer; SENL, supercritical extract of Neem leaves.