Table 5. List of ongoing RCTs comparing FT to whole gland treatment.
| Trial name | Chief investigator; Country | Estimated completion year | Target enrolment; status | Interventions | Primary outcome |
|---|---|---|---|---|---|
| NCT03668652 (FARP) | Baci; Sweden | 2024 | 250; recruiting | HIFU vs. RP | Treatment failure: (I) for HIFU: need for secondary whole-gland treatment (RP or EBRT); (II) for RP: PSA >0.2 ng/mL and need for EBRT |
| ISRCTN17249875 (PART) | Leslie; UK | 2026 | 800; recruiting | HIFU vs. radical treatment (RP or RT: EBRT or brachytherapy) | (I) Oncological outcomes (II) Side effects and patient-reported outcomes |
| NCT04278261 | Wang; China | 2027 | 438; not yet recruiting | IRE vs. RP | 5-year progression-free survival |
| NCT04049747 (CHRONOS-A) | Ahmed; UK | 2027 | 2450; recruiting | FT (HIFU or cryotherapy) vs. radical treatment (RP or RT: EBRT or brachytherapy) | Progression-free survival |
RCT, randomized clinical trial; FT, focal therapy; HIFU, high intensity focused ultrasound; RP, radical prostatectomy; EBRT, external beam radiotherapy; IRE, irreversible electroporation; FT, focal therapy; RT, radiotherapy; PSA, prostate-specific antigen.