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. 2022 Aug 4;6:24705470221105804. doi: 10.1177/24705470221105804

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© The Author(s) 2022

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Panels illustrate the relationships between in vivo mGluR5 availability in four brain regions orbitofrontal cortex (OFC; A), ventromedial prefrontal cortex (vmPFC; B), dorsolateral prefrontal cortex (dlPFC; C), hippocampus (D) and attention/ psychomotor speed (ATTN) assessed using a composite of the Cogstate identification (IDN) and detection (DET) tasks. mGluR5 availability in the PTSD group (blue, top row) was significantly negatively related to ATTN in all ROIs: OFC (r = −.441, P = .016), vmPFC (r = −.408, P = .028), dlPFC(r = −.421, P = .023), and hippocampus (r = −.422, P = .025). By contrast, mGluR5 availability in the MDD group (purple, middle row) was significantly positively related to ATTN in the OFC (r = .590, P = .006), vmPFC (r = .653, P = .002), and dlPFC (r = .620, P = .004) Findings in the hippocampus for MDD followed the same pattern, but did not survive correction for multiple comparisons (r = .480, P = .036). ATTN and mGluR5 availability were not significantly related in the HA group (gray, bottom row). Of note, in MANOVA analyses group*ATTN interaction results in the OFC did not survive multiple comparisons (P = .046).