Table 4.
Liver and Kidney Function Parameters of Plasmodium Berghei Infected Mice Administered with Curative Doses of Senna alata.
| Treatments | Parasitaemia (%) | Chemo-suppression (%) | Liver function parameters | Kidney function parameters | |||
|---|---|---|---|---|---|---|---|
| AST (UL−1) | ALT (UL−1) | ALP (UL−1) | Urea (mmol/L) | Creatinine (µmol/L) | |||
| Normal control | — | — | 16.40 ± 1.34 | 18.73 ± 0.56 | 50.6 ± 2.85 | 3.50 ± 0.04 | 55.67 ± 1.70 |
| Negative control | 29.83 ± 3.49 | 0.00 | 33.86 ± 1.09 | 50.36 ± 0.61 | 124.20 ± 4.28 | 4.79 ± 0.98 | 102.76 ± 2.91 |
| 25 mg/kg/day CQ | 1.17 ± 1.17a | 96.08 | 17.98 ± 0.84a | 22.16 ± 0.62a | 60.26 ± 2.08a | 4.04 ± 0.03 | 71.85 ± 1.38a |
| 200 mg/kg/day SAE | 4.50 ± 1.05ab** | 84.91 | 15.79 ± 0.82ab* | 22.53 ± 0.46a | 43.24 ± 2.25ab | 4.19 ± 0.03 | 67.97 ± 1.74ab** |
Values are presented as mean ± SD of six(6) determinations.
a < 0.001 compared with negative control.
b < 0.001, b* < 0.01, b** < 0.05 compared to CQ group.