Table 3. Association of ABCC2 haplotypes estimated phenotypic means for Mycophenolic acid pharmacokinetic parameters. Values for all individuals and subdivided by Calcineurin Inhibitor.

Phenotypic mean estimated from maximum likelihood methods by THESIAS; Phenotype reported as contribution of single haplotype (one chromosome region).

	All (N=147)			Cyclosporine Group (n=80)			Tacrolimus Group (n=67)
Mycophenolic Acid Pharmacokinetic Parameters	Phenotypic Mean (±95% CI) Wildtype Haplotype (CGC)	Phenotypic Mean (±95% CI) Variant Haplotype (CGT)	P value	Phenotypic Mean (±95% CI) Wildtype Haplotype (CGC)	Phenotypic Mean (±95% CI) Variant Haplotype (CGT)	P value	Phenotypic Mean (±95% CI) Wildtype Haplotype (CGC)	Phenotypic Mean (±95% CI) Variant Haplotype (CGT)	P value
CL/F (L/hr)	7.11(5.74 to 8.49)	11.04(8.80 to 13.27)	0.013	10.04 (7.9 to 12.18)	13.68 (10.7 to 16.66)	0.958	4.58 (3.53 tp 5.63)	7.22 (5.7 to 8.73)	0.014
AUC0-12hr (mg●hr/L)	31.06 (27.83 to 34.30)	18.03 (8.40 to 27.66)	0.017	21.11 (17.97 to 24.26)	16.64 (9.6 to 23.65)	0.890	39.96 (34.59 to 45.32)	20.06 (4.08 to 36.0)	0.031
Ratio MPAG AUC0-12hr / MPA AUC0-12hr	12.27 (9.73 to 14.81)	18.96 (13.45 to 24.47)	0.047	19.75 (16.19 to 23.3)	25.7 (17.53 to 33.86)	0.809	5.86 (4.86 to 7.02)	8.58 (6.21 to 10.95)	0.075
C12hr (mg/L)	1.63 (1.39 to 1.87)	1.01 (0.42 to 1.61)	0.078	0.965 (0.633 to 1.3)	0.783 (0.182 to 1.38)	0.597	2.25 (1.87 to 2.63)	1.33 (0.411 to 2.25)	0.081
AUC6-12hr	12.05 (10.6 to 13.5)	5.68 (−0.73 to 12.1)	0.064	6.67 (5.47 to 7.86)	5.11 (2.36 to 7.86)	0.091	17.09 (14.65 to 19.54)	6.37 (−7.57 to 20.31)	0.0148
AUC: area under the concentration time curve, C12hr: trough concentration 12 hours post-dose, CL/F: apparent oral clearance, MPA: mycophenolic acid, MPAG: mycophenolic acid glucuronide. Bonferroni corrected level of significance is 0.01 for multiple testing