. Author manuscript; available in PMC: 2022 Aug 9.

Published in final edited form as: J Clin Pharmacol. 2021 Jul 20;61(12):1592–1605. doi: 10.1002/jcph.1932

Table 4.

ANOVA Analysis of Mycophenolic Acid Pharmacokinetic parameters for individual ABCC2 SNPs.

		Mycophenolic acid AUC_0-12hr (hr●mg/L)		Mycophenolic acid Clearance (L/hr)		Ratio MPAG AUC_0-12hr / MPA AUC_0-12hr
Genotypes	N	Mean	StdDev	Mean	StdDev	Mean	StdDev
ABCC2 −24C>T (rs717620)
CC	110	55.44	29.30	16.21	10.32	28.94	21.70
CT	31	47.63	24.56	15.72	6.22	27.31	17.36
TT	6	51.38	24.37	13.33	4.52	29.27	13.19
All	147	53.63	28.21	15.99	9.41	28.61	20.49
		P = 0.39		P = 0.75		P = 0.93
ABCC2 1249 G>A (rs2273697)
GG	104	53.28	28.59	16.02	9.62	28.19	21.12
AG	39	54.39	28.08	15.76	9.15	28.73	19.03
AA	4	55.14	25.68	17.41	8.36	38.20	20.31
All	147	53.63	28.21	15.99	9.41	28.61	20.49
		P = 0.97		P = 0.95		P = 0.63
ABCC2 3972 C>T (rs 3740066)
CC	71	59.54	30.80	14.83	8.09	27.16	21.42
CT	55	48.89	26.12	17.13	11.60	29.12	19.62
TT	20	44.30	18.83	17.45	6.42	33.27	19.80
All	146	53.44	28.21	16.05	9.41	28.74	20.50
		P = 0.03		P = 0.31		P = 0.50

		LSD Post-hoc Test
			CC	CT
		CC
		CT	P = 0.034
		TT	P = 0.031	P = 0.53

Bonferroni corrected level of significance is 0.017 for multiple testing.