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. 2022 Aug 8;13:4615. doi: 10.1038/s41467-022-32312-1

Fig. 2. Age stratification of antibody responses.

Fig. 2

a Comparison between age groups: <60 (n = 178) and ≥60 (n = 134), at different time points (day 0, 21, 90 and 180) using SFB (left panel); RBD Roche S assay (middle panel); and sVNT assay (right panel). The median value of each age group is represented by the black line. The green dotted lines represent the maximum range of the samples for the whole cohort baseline as defined in Fig. 1. *p < 0.01, two-sided Mann–Whitney test. b Box plots showing difference in antibody response between days 180 and 90 for paired samples between the different age groups (<60 (n = 178) and ≥60 (n = 134)). Data are represented as median (middle line) with 25th, 75th percentile (box) and 5th and 95th (whiskers). Median values are −22.5 for <60 and 0.02 for ≥60 for the SFB assay; −358 for <60 and −72 for ≥60 for the Roche S assay; and −16.75 for <60 and −17.3 for ≥60 for the sVNT assay. ***p < 0.0001, two-sided Mann–Whitney test.