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. 2022 Aug 8;13:4615. doi: 10.1038/s41467-022-32312-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Comparison of antibody response of the vaccinees (n = 35) at days 21, 90 and 180 using the SFB assays with cells expressing either the Wuhan ancestral virus (W), the delta (D) or Omicron (O) variants of the Spike protein. Median values of the samples were at day 21, 90 and 180 respectively 39.8%, 37.9% and 20.2 for the Wuhan strain; 8.45%, 20% and 8.8% for Delta;0.13%, 4.5% and 1.1% for Omicron. **p < 0.001, two-sided Mann–Whitney test. b Comparison between age groups: <60 (n = 17) and ≥60 (n = 18), at different time points (days 21, 90 and 180) using SFB with cells expressing either the wild-type Wuhan ancestral virus (W) or the delta (D) or Omicron (O) variants of the Spike protein. The median value of each group is represented by a red line. They were respectively at days 21, 90 and 180: Wuhan ancestral strain, 39,8%, 45,4% and 19.1% (<60) and 9%, 28.7%, and 23.96% (≥60); Delta variant: 25.4%, 22.2% and 7% (<60) and 5%, 17.4%, and 9.5% (≥60); and Omicron variant: 0.8%, 5% and 7% (<60) and 0.06%, 3.8%, and 0.4% (≥60). **p < 0.001, Friedman test when the three strains were compared together, or two-sided Mann–Whitney test when the same strain was compared between the two age groups.