Fig. 3. Relationship of post-vaccination SARS-CoV-2 serum neutralizing antibodies in COVID convalescent and naïve adults with antibody affinity against SARS-CoV-2 spike protein.

Correlation analysis between serum PsVNA50 neutralization antibody titers generated following second and third vaccination of COVID exposed (n = 31) and unexposed naïve (n = 50) adults against vaccine-matched SARS-CoV-2 WA1 (a) and Omicron BA.1 (b) and BA.2 (c), and antibody affinity to spike protein of corresponding SARS-CoV-2 strain. Correlation analysis was performed using nonlinear regression model and associated Spearman’s correlation coefficients (r) and regression significance (p) are shown for two-sided statistical test.