Fig. 2.

Effects of daily, acute administration of escalating doses of cocaine or MDPV, or repeated saline injection, on the MAD of rats when drug-naïve (left) or following prolonged treatment of 3.0 mg/kg MDPV or 30.0 mg/kg cocaine, or saline (right). Abscissa: dose of drug (mg/kg), or saline (ml/kg), based on treatment group assigned. Ordinate: MAD expressed as a percent of the stability criteria. Group sizes below points indicate the number of subjects in the MDPV group that completed the session, at that dose. MDPV, 3,4-methylenedioxypyrovalerone.