TABLE 4.
Delayed-match-to-sample – delayed recognition performance by TBI and memory.
| #Subjects | Positive stim | NoStim | Negative stim | %Change positive stim | %Change negative stim | ||
| ALL STIM | |||||||
| Control | Impaired | 4 | 83.9% ± 1.6% | 73.6% ± 5.0% | 75.3% ± 5.5% | 13.9%** | 2.2% |
| Normal | 6 | 79.2% ± 6.3% | 68.6% ± 6.1% | 69.2% ± 8.9% | 15.4% | 0.9% | |
| RMBI | Impaired | 5 | 69.0% ± 8.5% | 58.6% ± 10.5% | 46.7% ± 11.3% | 17.6% | –20.4% |
| Normal | 2 | 91.3% ± 5.0% | 81.1% ± 2.2% | 92.2% ± 1.6% | 12.5%* | 13.6%** | |
| TBI | Impaired | 3 | 75.1% ± 3.9% | 51.5% ± 3.8% | 44.2% ± 7.1% | 45.8%** | –14.2% |
| Normal | 4 | 84.6% ± 3.7% | 84.9% ± 7.3% | 76.1% ± 6.2% | –0.3% | –10.4% | |
| MDM STIM | |||||||
| Control | Impaired | 4 | 83.1% ± 2.3% | 74.6% ± 4.3% | 74.0% ± 6.4% | 11.5%* | –0.7% |
| Normal | 6 | 77.8% ± 6.0% | 67.3% ± 7.8% | 69.9% ± 8.9% | 15.6% | 3.9% | |
| RMBI | Impaired | 3 | 71.0% ± 14.2% | 62.9% ± 15.3% | 58.0% ± 7.8% | 13.0% | –7.7% |
| Normal | 2 | 91.3% ± 5.0% | 81.1% ± 2.2% | 92.2% ± 1.6% | 12.5%* | 13.6%** | |
| TBI | Impaired | 2 | 77.2% ± 1.4% | 49.9% ± 3.4% | 51.3% ± 1.3% | 54.6%** | 2.8% |
| Normal | 2 | 80.1% ± 7.4% | 73.7% ± 16.5% | 65.6% ± 15.6% | 8.7% | –10.9% | |
| MIMO STIM | |||||||
| Control | Impaired | 1 | 83.3% | 58.1% | 68.6% | 43.3% | 18.0% |
| Normal | 3 | 91.8% ± 4.6% | 68.6% ± 8.5% | 67.0% ± 13.9% | 33.9%** | –2.3% | |
| RMBI | Impaired | 2 | 65.9% ± 10.0% | 52.3% ± 17.9% | 26.1% | –76.1% | |
| Normal | 0 | ||||||
| TBI | Impaired | 2 | 75.1% ± 7.8% | 55.8% ± 11.5% | 40.0% ± 10.0% | 34.7%* | –28.3% |
| Normal | 3 | 84.7% ± 4.3% | 85.5% ± 7.7% | 79.5% ± 4.5% | –1.0% | –7.0% | |
Stimulated and non-stimulated task performance sorted by TBI and memory for subjects receiving CA1 stimulation based on MDM and MIMO models. Positive stim = stimulation patterns derived from modeling correct DMS trials (MIMO) or from MDM patterns that were congruent with the content classification of the Sample/Match image. NoStim = trials with no stimulation delivered. Negative stim = trials with random stimulation patterns (MIMO) or from MDM that were not specific to the content classification of the Sample/Match image). Stimulation was only delivered during the Sample phase of DMS trials, and not delivered during Match phase, nor during the DR assessment. %Change = percentage of increase (+, no symbol) or decrease (–) compared to NoStim. Conditions with significant increase or decrease in DR performance relative to NoStim (*p < 0.01, **p < 0.001 by pairwise linear contrasts) are indicated by asterisks. Note, there were no Normal Memory RMBI subjects tested with MIMO stimulation.