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. Author manuscript; available in PMC: 2022 Aug 9.
Published in final edited form as: Mol Microbiol. 2020 Oct 16;115(2):290–304. doi: 10.1111/mmi.14616

FIGURE 2.

FIGURE 2

Distribution of Fpn proteases among the Bacteroidetes. An evolutionary tree of closely related orthologs of the Fpn protease produced by ETBF strain 20656-2-1 identified in the EggNOG database was constructed using Clustal Omega (http://www.clustal.org/omega/) and Phylogeny. Several P. gingivalis gingipains and the C. histolyticum CloSI protein were included for comparison. A taxonomic profile of the 39 closely related orthologs that were identified (group ENOG4108ZPA, 7.42e-142, score = 476.2) shows that all but one are produced by members of the Bacteroidetes. The 39th ortholog is produced by a Treponema species (*). Most of the closely related orthologs (~85%) are predicted by LipoP (http://www.cbs.dtu.dk/servi ces/LipoP/) to contain a lipobox motif