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. 2022 Aug 8;13:4631. doi: 10.1038/s41467-022-32324-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Calculated ex vivo frequencies of spike-specific CD8⁺ T cells throughout 1^st, 2^nd and 3^rd vaccination (a). Ki-67,and CD38 expression within spike-specific non-naïve CD8⁺ T cells (b). t-SNE representation of flow cytometry data comparing A*01/S₈₆₅- and A*02/S₂₆₉-specific CD8⁺ T cells at peak response after 1^st, 2^nd and 3^rd vaccination. Expression levels of CD38, T-BET, BCL-2, PD-1 and TOX are depicted (c). Statistical significance was determined by two-way ANOVA with main model (a, b) comparing the effects of targeted epitopes (p_e) and of the time course (p_t). Source data are provided as a Source Data file.