. Author manuscript; available in PMC: 2023 Jan 1.

Published in final edited form as: J Pharmacol Toxicol Methods. 2021 Oct 20;113:107129. doi: 10.1016/j.vascn.2021.107129

Table 3.

Efficacy of S1R ligands that function as agonists of BDNF secretion.

Compound	Efficacy of BDNF secretion
4-PPBP	1
Promethazine	1.09 ± 0.34
Cas# 1796909-31-3	0.24 ± 0.04*
(+)-igmesine	0.42 ± 0.03*
Donepezil	0.53 ± 0.08*
Carbetapentane	0.73 ± 0.05*
Oxeladin	0.55 ± 0.04*

Values are normalized to the maximal response of 10 μM 4-PPBP. Efficacies significantly different from 4-PPBP are marked with an asterisk (P < 0.05, one-way ANOVA, Bonferroni’s post-hoc). All other efficacies were not significantly different. Values represent mean ± SEM.