TABLE 2.
95% confidence interval (CI) and p‐value of the one‐sided Mann‐Whitney test
| Noninferiority test | ||||||
|---|---|---|---|---|---|---|
| Versa | Halcyon | 2100 v15.6 | ||||
| Structure, metric | 95% CI | p‐Value | 95% CI | p‐Value | 95% CI | p‐Value |
| Brain, max Dose | (−3.9, 5.0) | 0.299 | (−2.3, 6.7) | 0.516 | (−2.9, 6.5) | 0.421 |
| BrainStem, max Dose | (−0.7, 2.6) | 0.195 | (−1.3, 2.2) | 0.100 | (−1.3, 2.0) | 0.072 |
| Chiasm, max Dose | (−0.1, 0.7) | <0.001 | (−0.1, 0.6) | <0.001 | (−0.3, 0.5) | <0.001 |
| Cochlea_L, max dose | (−3.7, 2.9) | 0.123 | (−3.3, 3.5) | 0.175 | (−3.0, 4.3) | 0.267 |
| Cochlea_R, max dose | (−3.4, 2.6) | 0.099 | (−2.9, 3.8) | 0.161 | (−2.2, 4.8) | 0.272 |
| Con_Parotid, mean dose | (−1.3, 2.3) | 0.093 | (−2.3, 1.3) | 0.020 | (−1.6, 2.0) | 0.064 |
| Eye_L, max dose | (−0.2, 0.6) | <0.001 | (−0.4, 0.4) | <0.001 | (−0.4, 0.5) | <0.001 |
| Eye_R, max dose | (−0.2, 0.6) | <0.001 | (−0.4, 0.5) | <0.001 | (−0.4, 0.6) | <0.001 |
| Ips_Parotid, mean dose | (−2.2, 3.4) | 0.202 | (−3.1, 2.5) | 0.099 | (−2.5, 3.0) | 0.147 |
| Lens_L, max dose | (0.0, 0.6) | <0.001 | (−0.1, 0.4) | <0.001 | (−0.2, 0.3) | <0.001 |
| Lens_R, max dose | (0.1, 0.6) | <0.001 | (−0.1, 0.3) | <0.001 | (−0.2, 0.3) | <0.001 |
| Mandible, max dose | (−1.7, 1.3) | 0.023 | (−1.6, 1.2) | 0.025 | (−1.5, 1.5) | 0.034 |
| OpticNrv_L, max dose | (−0.2, 0.7) | <0.001 | (−0.2, 0.6) | <0.001 | (−0.4, 0.5) | <0.001 |
| OpticNrv_R, max dose | (−0.2, 0.7) | <0.001 | (−0.2, 0.6) | <0.001 | (−0.3, 0.5) | <0.001 |
| SpinalCord, max dose | (0.0, 1.5) | 0.014 | (−0.9, 0.7) | <0.001 | (−0.6, 0.8) | <0.001 |
| zBrainStem_05, max dosea | (−1.0, 3.1) | 0.303 | (−0.5, 3.8) | 0.477 | (−1.0, 3.2) | 0.349 |
| zPTV1, D95% | (−1.0, 0.2) | 0.003 | (−0.8, 0.3) | 0.002 | (−0.5, 0.5) | 0.001 |
| zPTV1, D98% | (−1.3, 0.2) | 0.011 | (−1.1, 0.3) | 0.005 | (−0.7, 0.6) | 0.002 |
| zPTV1, V100% | (−3.0, ‐1.0) | 0.024 | (−3.0, 0.0) | 0.021 | (−1.0, 1.0) | <0.001 |
| zPTV1, V105% | (1.0, 1.0) | <0.001 | (1.0, 1.0) | <0.001 | (0.0, 0.0) | <0.001 |
| zPTV1, V95% | (0.0, 0.0) | <0.001 | (0.0, 0.0) | <0.001 | (0.0, 0.0) | <0.001 |
| zPTV2, D95% | (−1.2, 0.3) | 0.006 | (−1.3, 0.3) | 0.007 | (−0.7, 0.9) | 0.001 |
| zPTV2, D98% | (−1.3, 0.3) | 0.008 | (−1.4, 0.2) | 0.009 | (−0.7, 0.8) | <0.001 |
| zPTV2, V100% | (−4.0, ‐1.0) | 0.312 | (−5.0, −1.0) | 0.440 | (−1.0, 2.0) | <0.001 |
| zPTV2, V105% | (2.0, 8.0) | 0.864 | (1.0, 8.0) | 0.813 | (−5.0, 2.0) | 0.030 |
| zPTV2, V110% | (0.0, 1.0) | 0.002 | (0.0, 2.0) | 0.003 | (−1.0, 1.0) | <0.001 |
| zPTV2, V95% | (−1.0, 0.0) | <0.001 | (−1.0, 0.0) | <0.001 | (0.0, 0.0) | <0.001 |
| zPTV3, D95% | (−0.4, ‐0.1) | <0.001 | (−0.5, −0.2) | <0.001 | (−0.2, 0.0) | <0.001 |
| zPTV3, D98% | (−0.5, ‐0.2) | <0.001 | (−0.6, −0.3) | <0.001 | (−0.2, 0.1) | <0.001 |
| zPTV3, V100% | (−2.0, ‐1.0) | <0.001 | (−2.0, −1.0) | 0.002 | (−1.0, 0.0) | <0.001 |
| zPTV3, V105% | (5.0, 8.0) | 0.978 | (7.0, 9.0) | 0.997 | (−2.0, 0.0) | 0.018 |
| zPTV3, V110% | (0.0, 1.0) | <0.001 | (1.0, 2.0) | 0.018 | (0.0, 0.0) | <0.001 |
| zPTV3, V95% | (0.0, 0.0) | <0.001 | (−1.0, 0.0) | <0.001 | (0.0, 0.0) | <0.001 |
| zSpinalCord_05, max dosea | (−0.2, 1.7) | 0.133 | (−0.9, 1.2) | 0.054 | (−0.4, 1.5) | 0.099 |
Abbreviations: DX%, doses at the given percent of target coverage; D max, maximum dose; D mean, mean dose; VX%, percent of the target receiving the prescribed dose.
a
Structure with a 5 mm margin.