Table 4.
Associations between father’s exposure to organic dust and childhood leukemia and CNS stratified by exposure to pesticides in pooled data from five cohorts1
| Diagnostic Group | Exposure | Organic Dust Exposure | Cases | Hazard Ratio2 | 95% CI | |
|---|---|---|---|---|---|---|
|
| ||||||
| Any Leukemia | No Pesticides | None | 112 | Ref | ||
| Any | 18 | 0.87 | 0.53 | 1.44 | ||
| Any Pesticides | None | 0 | - | - | - | |
| Any | 7 | 0.89 | 0.42 | 1.92 | ||
| ALL | No Pesticides | None | 91 | Ref | ||
| Any | 10 | 0.59 | 0.31 | 1.14 | ||
| Any Pesticides | None | 0 | - | - | - | |
| Any | 3 | 0.48 | 0.15 | 1.50 | ||
| AML3 | No Pesticides | None | 18 | Ref | ||
| Any | 7 | 2.12 | 0.88 | 5.12 | ||
| Any Pesticides | None | 0 | - | - | - | |
| Any | 4 | 3.07 | 1.03 | 9.10 | ||
| CNS tumors3 | No Pesticides | None | 99 | Ref | ||
| Any | 19 | 1.05 | 0.64 | 1.72 | ||
| Any Pesticides | None | 0 | - | - | - | |
| Any | 5 | 0.72 | 0.29 | 1.76 | ||
1
All models were stratified by cohort to allow each cohort to have a different baseline hazard. DNBC and MoBa provided all childhood cancer cases and a 10% random sample of their cohorts. These data were weighted to represent the entire cohorts.
2
Adjusted for child’s sex and paternal age
3
CNS tumor analyses were conducted with four cohorts, ALPSAC did not provide data on CNS tumor cases due to data protection/IRB issues associated with small numbers and there were no cases of AML found in this cohort