Table 7.
Predictive ability of the risk factors for predicting osteoporosis and osteopenia by gender.
| Variables | Disease for predicting | Optimal cutoffs | Sensitivity | Specificity | AUC | 95%CI | P value | ||
|---|---|---|---|---|---|---|---|---|---|
| Male | |||||||||
| β-CTx (ng/mL) | Osteoporosis | 0.20 | 0.794 | 0.595 | 0.714 | 0.630~0.798 | <0.001 | ||
| Osteopenia +osteoporosis | 0.21 | 0.620 | 0.640 | 0.636 | 0.570~0.702 | <0.001 | |||
| PINP (ng/mL) | Osteoporosis | 28.97 | 0.841 | 0.494 | 0.671 | 0.583~0.759 | <0.001 | ||
| Osteopenia +osteoporosis | 28.90 | 0.741 | 0.494 | 0.634 | 0.565~0.703 | <0.001 | |||
| Osteocalcin-OST (ng/mL) | Osteoporosis | 13.65 | 0.381 | 0.921 | 0.677 | 0.591~0.763 | <0.001 | ||
| Osteopenia +osteoporosis | 7.35 | 0.867 | 0.303 | 0.598 | 0.531~0.665 | 0.006 | |||
| Grip strength of left hand (Kg) | Osteoporosis | 33.80 | 0.640 | 0.675 | 0.671 | 0.548~0.758 | <0.001 | ||
| Osteopenia +osteoporosis | 33.55 | 0.625 | 0.622 | 0.648 | 0.584~0.713 | <0.001 | |||
| Grip strength of right hand (Kg) | Osteoporosis | 35.45 | 0.640 | 0.625 | 0.660 | 0.573~0.748 | 0.001 | ||
| Osteopenia +osteoporosis | 32.55 | 0.764 | 0.472 | 0.640 | 0.576~0.704 | <0.001 | |||
| β-CTx+ PINP+ OST | Osteoporosis | – | – | – | 0.708 | 0.623~0.792 | <0.001 | ||
| Osteopenia +osteoporosis | – | – | – | 0.649 | 0.583~0.715 | <0.001 | |||
| Familial Alzheimer Disease+ Height loss (>3cm) + Both Hand Grip strength | Osteoporosis | – | – | – | 0.730 | 0.642~0.817 | <0.001 | ||
| Osteopenia +osteoporosis | – | – | – | 0.672 | 0.600~0.743 | <0.001 | |||
| Familial Alzheimer Disease+ Height loss (>3cm) + Both Hand Grip strength+β-CTx+ PINP+ OST | Osteoporosis | – | – | – | 0.797 | 0.715~0.879 | <0.001 | ||
| Osteopenia +osteoporosis | – | – | – | 0.717 | 0.652~0.780 | <0.001 | |||
| Female | |||||||||
| β-CTx (ng/mL) | Osteoporosis | 0.27 | 0.591 | 0.743 | 0.707 | 0.661~0.752 | <0.001 | ||
| Osteopenia +osteoporosis | 0.27 | 0.533 | 0.739 | 0.675 | 0.632~0.718 | <0.001 | |||
| Parathyroid hormone-PTH (pmol/L) | Osteoporosis | 3.68 | 0.369 | 0.754 | 0.573 | 0.523~0.623 | 0.005 | ||
| Osteopenia +osteoporosis | 3.67 | 0.349 | 0.750 | 0.552 | 0.507~0.598 | 0.029 | |||
| Osteocalcin-OST (ng/mL) | Osteoporosis | 14.66 | 0.529 | 0.840 | 0.731 | 0.688~0.773 | <0.001 | ||
| Osteopenia +osteoporosis | 14.53 | 0.472 | 0.830 | 0.691 | 0.651~0.732 | <0.001 | |||
| Age of menarche (Year) | Osteoporosis | 13.50 | 0.718 | 0.454 | 0.613 | 0.563~0.663 | <0.001 | ||
| Osteopenia +osteoporosis | 13.50 | 0.684 | 0.451 | 0.581 | 0.534~0.627 | 0.001 | |||
| Alkaline phosphatase-ALP (U/L) | Osteoporosis | 71.50 | 0.663 | 0.640 | 0.682 | 0.635~0.729 | <0.001 | ||
| Osteopenia +osteoporosis | 71.50 | 0.613 | 0.642 | 0.656 | 0.611~0.700 | <0.001 | |||
| PINP (ng/mL) | Osteoporosis | 37.13 | 0.768 | 0.474 | 0.652 | 0.605~0.700 | <0.001 | ||
| Osteopenia +osteoporosis | 38.16 | 0.724 | 0.500 | 0.636 | 0.592~0.680 | <0.001 | |||
| Grip strength of left hand (Kg) | Osteoporosis | 19.91 | 0.864 | 0.459 | 0.709 | 0.664~0.753 | <0.001 | ||
| Osteopenia +osteoporosis | 24.05 | 0.599 | 0.695 | 0.659 | 0.612~0.707 | <0.001 | |||
| Grip strength of right hand (Kg) | Osteoporosis | 22.25 | 0.780 | 0.521 | 0.689 | 0.643~0.735 | <0.001 | ||
| Osteopenia +osteoporosis | 22.65 | 0.743 | 0.487 | 0.626 | 0.576~0.677 | <0.001 | |||
| Age of menopause (Year) | Osteoporosis | 49.50 | 0.764 | 0.420 | 0.627 | 0.575~0.680 | <0.001 | ||
| Osteopenia +osteoporosis | 49.50 | 0.757 | 0.400 | 0.612 | 0.561~0.662 | <0.001 | |||
| Duration of menstruation (Day) | Osteoporosis | 4.50 | 0.861 | 0.274 | 0.565 | 0.516~0.614 | 0.013 | ||
| Osteopenia +osteoporosis | – | – | – | – | – | – | |||
| β-CTx+ PINP+ OST+ ALP+ PTH | Osteoporosis | – | – | – | 0.760 | 0.719~0.801 | <0.001 | ||
| Osteopenia +osteoporosis | – | – | – | 0.716 | 0.676~0.757 | <0.001 | |||
| Fracture+ Height loss (>3cm) + Steatohepatitis+ hands Grip strength + Age of menarche+ Age of menopause +Duration of menstruation | Osteoporosis | – | – | – | 0.769 | 0.724~0.813 | <0.001 | ||
| Osteopenia +osteoporosis | – | – | – | 0.692 | 0.646~0.738 | <0.001 | |||
| β-CTx+ PINP+ OST+ ALP+ PTH + Fracture+ Height loss (>3cm) + Steatohepatitis+ hands Grip strength + Age of menarche+ Age of menopause +Duration of menstruation | Osteoporosis | – | – | – | 0.826 | 0.787~0.864 | <0.001 | ||
| Osteopenia +osteoporosis | – | – | – | 0.753 | 0.711~0.795 | <0.001 | |||
All variables are analyzed after adjustment by age and BMI. β-CTx stands for β cross-linked C-telopeptide of type 1 collagen; PINP represents Procollagen type 1 N-terminal propeptide.
The bold type is used when the AUC value > 0.7.