Table 5.
Concentrations of inflammatory biomarkers in healthy controls and cases groups for adjusted age (≤40 years).
| Parameters | Healthy Controls, n=126, Median (IQR) | Cases, n=54, Median (IQR) | P-value |
|---|---|---|---|
| CRP (mg/L) | 1(0.4, 2.4) | 67.50 (12.5,115.3) | <.0001* |
| ICAM-1(mg/L) | 0.5 (0.4, 0.6) | 0.86 (0.5, 1.29) | <.0001* |
| SAA (mg/L) | 1. 9 (1.2, 3.6) | 131 (17, 508.8) | <.0001* |
| VCAM-1(mg/L) | 0.6 (0.5, 0.7) | 0.9 (0.7, 1.1) | <.0001* |
| CCL11 (ng/L) | 153.8 (89.3,244.6) | 90.7 (57.8,145.8) | <.0001* |
| CCL26 (ng/L) | 21.6 (13.4, 32.2) | 26.8 (20.8, 37.5) | .0053 |
| CXCL10 (ng/L) | 145.1 (96.9, 191.8) | 463.4 (159.8,1944) | <.0001* |
| CCL2 (ng/L) | 45.9 (34.5, 72.4) | 45.6 (35.6, 86.5) | .6157 |
| CCL13 (ng/L) | 92.2 (59.8, 138.2) | 60.6 (49.8, 92.8) | .0005* |
| CCL22 (ng/L) | 723.7 (600.9,876.1) | 501.1 (308.7,743) | <.0001* |
| CCL3 (ng/L) | 7.4 (5.3, 9.6) | 12.9 (9.1, 18.3) | <.0001* |
| CCL4 (ng/L) | 69.9 (53.9, 87.6) | 59.6 (48, 81.8) | .0460 |
| CCL17 (ng/L) | 187.7 (106.5, 265.5) | 63.7 (41.6,152.9) | <.0001* |
| IFN-Ƴ (ng/L) | 3.2 (2.2, 5.5) | 4 (1.7, 19.1) | .0376 |
| IL-10 (ng/L) | 0.2 (0.1, 0.3) | 0.8 (0.3, 2.7) | <.0001* |
| IL-12p70 (ng/L) | 0.2 (0.2, 0.3) | 0.2 (0.2, 0.4) | .3699 |
| IL-13 (ng/L) | 0.8 (0.4, 1.3) | 1.1 (0.8,1.7) | .0036 |
| IL-1β (ng/L) | 0.2 (0.1, 0.2) | 0.1 (0.0, 0.3) | .0974 |
| IL-2 (ng/L) | 0.5 (0.3, 0.8) | 0.7 (0.5, 1.1) | .0016 |
| IL-4 (ng/L) | 0.03 (0.02, 0.04) | 0.04 (0.02, 0.06) | .1804 |
| IL-6 (ng/L) | 0.4 (0.3, 0.6) | 3.6 (1.8, 10.7) | <.0001* |
| IL-8 (ng/L) | 6.8 (4.4, 9.3) | 11.1 (6.1, 34.2) | <.0001* |
| TNF-α (ng/L) | 1.2 (0.9, 1.5) | 1.6 (1.1, 2.6) | .0012* |
| GM-CSF (ng/L) | 0.0 (0.0, 0.04) | 0.04 (0.0, 0.2) | .0002* |
| IL-12/IL-23p40 (ng/L) | 59.2 (47.3, 77.2) | 54.4 (13.4, 84.8) | .1528 |
| IL-15 (ng/L) | 1.2 (1, 1.4) | 2.9 (1.8, 5.2) | <.0001* |
| IL-16 (ng/L) | 200 (134.3, 590.3) | 126.5 (94.3,202.7) | <.0001* |
| IL-17A (ng/L) | 1.5 (1, 2) | 1.9 (0.9, 3.4) | .2010 |
| IL-1α (ng/L) | 1.5 (0.9, 2.4) | 2.5 (1.9, 3.5) | <.0001* |
| IL-5 (ng/L) | 0.28 (0.1, 0.6) | 0.26 (0.1, 0.7) | .7479 |
| IL-7 (ng/L) | 2.5 (1.8, 4.1) | 3.3 (1.9, 5.8) | .0595 |
| TNF-β (ng/L) | 0.14 (0.1, 0.2) | 0.12 (0.07, 0.16) | .0283 |
| VEGF (ng/L) | 127.6 (60.1, 238.1) | 41.7 (12.4, 167.8) | <.0001* |
| Flt-1 (ng/L) | 83.2 (66.1, 100.7) | 214.2 (136.5,618.) | <.0001* |
| PlGF (ng/L) | 3.9 (3.3, 4.4) | 7.8 (4.9, 11.2) | <.0001* |
| Tie-2 (ng/L) | 3284 (2683, 3845) | 2098 (1731, 2549) | <.0001* |
| VEGF-C (ng/L) | 206.5 (146.3,324.3) | 113.5 (45.1,195.2) | <.0001* |
| VEGF-D (ng/L) | 1335 (975.1,1882) | 1493 (918.4, 2496) | .1389 |
| bFGF (ng/L) | 5.3 (2.9, 17.1) | 12.6 (4.1, 31.3) | .0208 |
Bold p value emphasizes 0.05 criteria met. *p value emphasizes Bonferroni (0.05/39) criteria met.