Table 7.
Area under the receiver operating characteristic curve, sensitivity, specificity & cutoff values of specific inflammatory markers of distinguishing healthy controls and cases.
| Variable | AUC (95% CI) | Sensitivity % (95% CI) | Specificity% (95% CI) | Cutoff | P-value |
|---|---|---|---|---|---|
| CRP | 0.9817(0.9703-0.9931) | 75.4(67.2-82.1) | 100(97.2- 100) | > 22.50 | <.0001 |
| SAA | 0.9783(0.9610-0.9956) | 88.9(82.2- 93.3) | 99.3(95.9-99.9) | > 11.50 | <.0001 |
| IL-6 | 0.9634(0.9425-0.9843) | 82.5(74.9- 88.2) | 97.8(93.6- 99.4) | > 1.49 | <.0001 |
| IL-8 | 0.7800(0.7238-0.8362) | 38.1(30.1- 46.8) | 97.8(93.6- 99.4) | > 18.92 | <.0001 |
| CXCL10 | 0.8735(0.8265-0.9204) | 69.8(61.3- 77.2) | 97.8(93.6- 99.4) | > 374.2 | <.0001 |
| TNF-α | 0.7168(0.6521-0.7816) | 30.9(23.5- 39.5) | 97.8(93.6- 99.4) | > 2.505 | <.0001 |
| IL-10 | 0.8793(0.8328- 0.9257) | 53.2(44.5- 61.7) | 97.8(93.6- 99.4) | > 1.010 | <.0001 |
| VEGF-D | 0.5059(0.4347- 0.5772) | 3.9(1.7- 8.9) | 97.8(93.6- 99.4) | < 429.9 | .8689 |
| CCL22 | 0.7894(0.7324- 0.8463) | 46.8(38.3- 55.5) | 97(92.6 - 98.8) | < 418.8 | <.0001 |
| VCAM-1 | 0.8465(0.7960- 0.8971) | 32.5(24.9- 41.1) | 98.5(94.7- 99.7) | > 1.215 | <.0001 |
Bold p value emphasizes 0.05 criteria met. Cut off value units for CRP, SAA and VCAM-1 were (mg/L) and IL-6, IL-8, CXCL10, TNF-α, IL-10, VEGF-D and CCL22 were (ng/L).