Table 8.
Area under the receiver operating characteristic curve, sensitivity, specificity & cutoff values of specific markers in discriminating mild/moderate and severe COVID-19 patients.
| Variable | AUC (95% CI) | Sensitivity % (95% CI) | Specificity% (95% CI) | Cutoff | P-value |
|---|---|---|---|---|---|
| CRP | 0.6743(0.5799- 0.7687) | 7.4(3.2 - 16.1) | 98.3(90.9-99.9) | > 395 | .0008 |
| SAA | 0.7031(0.6115 -0.7947) | 5.9(2.3- 14.2) | 98.3(90.9- 99.9) | > 1074 | <.0001 |
| IL-6 | 0.5710(0.4696 -0.6724) | 11.8(6.1- 21.5) | 100(93.8- 100) | > 77.72 | .1705 |
| IL-8 | 0.5033(0.4015- 0.6051) | 7.4(3.2- 16.1) | 100(93.8 - 100) | > 305.7 | .9493 |
| CXCL10 | 0.7155(0.6263- 0.8047) | 20.6(12.7- 31.6) | 98.3(90.9- 99.9) | > 5185 | <.0001 |
| TNF-α | 0.5267(0.4246 -0.6289) | 1.5(0.1- 7.9) | 98.3(90.9- 99.9) | > 36.32 | .6056 |
| IL-10 | 0.6557(0.5589- 0.7524) | 2.9(0.5 - 10.1) | 100(93.8- 100) | > 46.46 | .0027 |
| VEGF-D | 0.6389(0.5404-0.7375) | 7.4(3.2 -16.1) | 96.6(88.3- 99.4) | < 482.3 | .0073 |
| CCL22 | 0.6498(0.5495-0.7502) | 4.4(1.2- 12.2) | 93.1(83.6- 97.3) | < 156.1 | .0038 |
| VCAM-1 | 0.6337(0.5364 -0.7311) | 2.9(0.5- 10.1) | 98.3(90.9- 99.9) | > 2.120 | .0098 |
Bold p value emphasizes 0.05 criteria met. Cut off value units for CRP, SAA and VCAM-1 were (mg/L) and IL-6, IL-8, CXCL10, TNF-α, IL-10, VEGF-D and CCL22 were (ng/L).