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. 2022 Jul 25;13:955390. doi: 10.3389/fimmu.2022.955390

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Copyright © 2022 Liu, Zhang, Ju, Wang and Qie

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Single-cell atlas of the HCC and tumor-adjacent tissues. (A) Overview of the cell clusters based on scRNA-seq data from tumor-adjacent and HCC tissues (UMAP). (B) The frequency of cells in each cluster. (C) Heatmap showing the expression of marker genes in the indicated cell types. The bottom bars label the clusters corresponding to specific cell types, and the number in brackets corresponds to the cluster number in panel (A, D) Histogram indicating the proportion of cells. HCC, hepatocellular carcinoma; scRNA-seq, single-cell RNA sequencing; UMAP, uniform manifold approximation and projection.