TABLE 3.
Association of vitamin D concentrations with incident psoriasis in different BMI categories.
| Vitamin D concentration, nmol/L | Normal (BMI < 25) |
Overweight (25 < BMI < 30) |
Obesity (BMI > 30) |
|||||||||
| N | Person-years | HR (95%CI) | p | N | Person-years | HR (95% CI) | p | N | Person-years | HR (95% CI) | p | |
| Per SD in concentration | 744 | 1,551,468 | 0.945 (0.880–1.015) | 0.119 | 1,234 | 1,978,052 | 0.951 (0.898–1.006) | 0.082 | 869 | 1,127,639 | 0.895 (0.838–0.956) | 0.001 |
| Quartiles | ||||||||||||
| 12.7–32.6 | 181 | 330,338 | Ref | 303 | 455,722 | Ref | 326 | 367,308 | Ref | |||
| 32.6–46.8 | 152 | 352,207 | 0.802 (0.646–0.995) | 0.045 | 320 | 498,491 | 0.963 (0.823–1.128) | 0.643 | 228 | 316,920 | 0.826 (0.697–0.978) | 0.027 |
| 46.8–62.0 | 199 | 391,839 | 0.941 (0.768–1.153) | 0.559 | 309 | 516,263 | 0.887 (0.757–1.041) | 0.142 | 187 | 257,300 | 0.841 (0.702–1.007) | 0.059 |
| 62.0–104.0 | 212 | 477,084 | 0.812 (0.664–0.992) | 0.042 | 302 | 507,576 | 0.869 (0.740–1.020) | 0.086 | 128 | 186,111 | 0.789 (0.643–0.968) | 0.023 |
| ptrend = 0.091 | ptrend = 0.261 | ptrend = 0.045 | ||||||||||
| Category | ||||||||||||
| Deficient (<25) | 96 | 168,700 | Ref | 161 | 226,571 | Ref | 202 | 196,235 | Ref | |||
| Insufficient (25∼50) | 274 | 596,057 | 0.833 (0.659–1.052) | 0.125 | 531 | 843,323 | 0.887 (0.743–1.059) | 0.184 | 401 | 551,175 | 0.724 (0.611–0.858) | <0.001 |
| Optimal (> 50) | 374 | 786,711 | 0.853 (0.680–1.071) | 0.170 | 542 | 908,158 | 0.823 (0.689–0.983) | 0.031 | 266 | 380,229 | 0.701 (0.583–0.843) | <0.001 |
| ptrend = 0.294 | ptrend = 0.086 | ptrend < 0.001 | ||||||||||
All models were adjusted for sex, age, income, education, smoking status, and vitamin D supplements.