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. 2022 Jul 25;13:955671. doi: 10.3389/fimmu.2022.955671

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Copyright © 2022 Deng, Zhu, Zhu, Sun, Ding, Li, Jian, Zhao, Deng, Deng, Deng, Guo, Sun, Lai, Tang, Cui, Ge and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SVV decreased Mfn2 expression, inhibited NLRP3 inflammasome activation. (A–C) The western blot assay for Mfn2, NLRP3, ASC, caspase1/p10/p20, cleaved-IL-1β and IL-18. (D–I) The relative protein expression level of Mfn2, NLRP3, ASC, caspase1/p10/p20, cleaved-IL-1β and IL-18. Unpaired T-test were used to investigate the significance of differences between the experimental groups and the control group *; P < 0.05, ***; P < 0.005,.