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. 2022 Jul 25;13:955671. doi: 10.3389/fimmu.2022.955671

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Copyright © 2022 Deng, Zhu, Zhu, Sun, Ding, Li, Jian, Zhao, Deng, Deng, Deng, Guo, Sun, Lai, Tang, Cui, Ge and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IRF7 inhibitor (BX795) inhibited IRF7 phosphorytion and IFN-λ3 secretion thus promote SVV proliferation. (A) The western blot assay for p-IRF7. (B)The relative protein expression level of IRF3. (C, D) The Elisa assay for IFN-λ1 and IFN-λ3. (E) The qRT-PCR assay for SVV copy number. One-way analysis of variance (ANOVA) were used to investigate the significance of differences between the SVV groups and the SVV+BX795 group or between the control group and SVV group *; P < 0.05, **; P < 0.01, ***; P < 0.005, ****; P < 0.001, ns means no significance.