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. 2022 Jul 25;13:955671. doi: 10.3389/fimmu.2022.955671

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Copyright © 2022 Deng, Zhu, Zhu, Sun, Ding, Li, Jian, Zhao, Deng, Deng, Deng, Guo, Sun, Lai, Tang, Cui, Ge and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mfn2 overexpression restrain SVV-induced RIG-I/IRF7 protein expression level and IFN-λ3 content in supernatant in PK-15 cells (A) The western blot assay for RIG-I and p-IRF7. (B, C) The relative protein expression level of RIG-I and p-IRF7. (D) The Elisa assay for IFN-λ3 detection. Unpaired T-test and One-way analysis of variance (ANOVA) were used to investigate the significance of differences. * means the difference between the WT and Ad-Mfn2 in control group; # means the difference between the WT and Ad-Mfn2 in SVV group. *; P < 0.05, **^,##; P < 0.01, ***^,###; P < 0.005, ^####; P < 0.001, ns means no significance.