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. 2022 Jul 25;13:955671. doi: 10.3389/fimmu.2022.955671

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Copyright © 2022 Deng, Zhu, Zhu, Sun, Ding, Li, Jian, Zhao, Deng, Deng, Deng, Guo, Sun, Lai, Tang, Cui, Ge and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mfn2 overexpression induced SVV-inhibited NLRP3 inflammasome activation in PK-15 cells. (A) The western blot assay for NLRP3, ASC, caspase1/p10/p20, cleaved-IL-1β and IL-18. (B–F) The relative protein expression level of NLRP3, ASC, caspase1/p10/p20, cleaved-IL-1β and IL-18. One-way analysis of variance (ANOVA) were used to investigate the significance of differences. * means the difference between the WT and Ad-Mfn2 in control group; # means the difference between the WT and Ad-Mfn2 in SVV group; and other groups. ^##; P < 0.01, ^###; P < 0.005, ****^,####; P < 0.001, ns means no significance.