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. 2022 Jul 25;12:913815. doi: 10.3389/fcimb.2022.913815

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Copyright © 2022 Wang, Liu, Xu, Wang, Wang, Zhang, Ni, Zhen, Xu, Liu, Fang, Huang and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The epigenetic modifications of bacteria-introduced lncRNA. (A) LPS induced an elevated level of lactic acid in HCT116 cells. (B) The expression of LINC00152 level in the lactic acid-treated cells (N=3). (C) The level of histone lysine lactylation in the LPS treated cells (N=3). (D) ChIP-qPCR revealed that the binding signaling of H4K8la to the LINC00152 promoter regions was higher than in the LPS treated cells compared with control group (N=3). (E) The expression of YY1 upon LPS and lactic acid treatment (N=2). (F) LPS reduced the binding efficiency of YY1 to the LINC00152 promoter compared with the control group (N=3). *P < 0.05; **P < 0.01 ***P < 0.001.