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. 2022 Aug 4;14(1):2107814. doi: 10.1080/20002297.2022.2107814

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Oral manifestation in recipient mice after human oral microbiome transplantation. (a) microCT images of periodontal tissues at endpoint; scale bar: 1 mm; (b) TRAP staining. Boxes in upper panel are shown magnified in lower panel; scale bar: 50 μm. (c) IHC staining of TNF-α (upper panel) and IL-1β (lower panel); scale bar: 50 μm. AOD quantification of TNF-α (d) and IL-1β (e) in IHC images. HSDM: healthy subject donated microbiome recipient mice; PPDM: periodontitis patient donated microbiome recipient mice; *(p < 0.05) indicates statistically significant difference between groups. N.S: not significant. N = 3 for each group.