Table 4.
AD Dementia sex-stratified analysis
| AD males | AD females | |||||||||||
| CHR | SNP | BP | MAF cases | MAF controls | OR (95% CI) | p | MAF cases | MAF controls | OR (95% CI) | p | LOC | GENE/LOCUS |
| 1 | rs140076909 | 98808256 | 0.0614 | 0.0150 | 4.506 (2.636–7.702) | 3.72E-08 | 0.0137 | 0.0199 | 0.6622 (0.261–1.678) | 0.3849 | Intergenic | LOC729987/ SNX7 |
| 7 | rs117803234 | 7155404 | 0.0711 | 0.0195 | 3.765 (2.325–6.096) | 6.936E-08 | 0.0082 | 0.0286 | 0.2777 (0.086–0.895) | 0.03183 | Intergenic | LOC100131257/ C1GALT1 |
| 12 | rs148760255 | 28755421 | 0.0417 | 0.0179 | 2.578 (1.436–4.631) | 1.523E-03 | 0.0495 | 0.0118 | 4.876 (2.545–9.340) | 1.785E-06 | Intergenic | CCDC91/ LOC105369711 |
| 12 | rs148377161 | 28830097 | 0.0417 | 0.0183 | 2.500 (1.395–4.482) | 2.090E-03 | 0.0549 | 0.0138 | 4.537 (2.469–8.336) | 1.104E-06 | Intergenic | CCDC91/ LOC105369711 |
| 12 | rs192213585 | 28918097 | 0.0441 | 0.0183 | 2.679 (1.510–4.753) | 7.565E-04 | 0.0522 | 0.0148 | 4.066 (2.207–7.493) | 6.865E-06 | Intergenic | CCDC91/ LOC105369711 |
| 19 | rs429358 | 45411941 | 0.1789 | 0.1075 | 1.875 (1.400–2.511) | 2.433E-05 | 0.2363 | 0.1130 | 2.722 (2.002–3.703) | 1.740E-10 | Exonic | APOE |
| 19 | rs769449 | 45410002 | 0.1373 | 0.0888 | 1.662 (1.206–2.290) | 0.001909 | 0.1868 | 0.0895 | 2.568 (1.842–3.580) | 2.697E-08 | Intronic | APOE |
CHR, chromosome; SNP, single-nucleotide polymorphism; BP, base-pair position based on GRCh37 assembly; A1, effect allele; MAF, minor allele frequency of the effect allele; OR, odds ratio with 95% confidence interval; LOC, location of the SNP.