Table 4.
Univariate and multivariate logistic regression analyses for short-term reversibility of renal function.
| Univariate analysis |
Multivariate analysis |
|||
|---|---|---|---|---|
| Variables | OR (95% CI) | p | OR (95% CI) | p |
| Age | 1.01 (1.00–1.01) | .002 | – | – |
| Male gender | 0.92 (0.77–1.08) | .287 | – | – |
| Ethnicity | 0.96 (2.52–3.07) | .810 | – | – |
| BMI | 0.98 (0.95–1.00) | .198 | – | – |
| Cardiovascular disease | 0.91 (0.85–0.98) | .012 | – | – |
| Chronic pulmonary disease | 0.94 (0.79–1.13) | .531 | – | – |
| Diabetes | 1.07 (0.89–1.28) | .494 | – | – |
| Sepsis | 0.35 (0.28–0.43) | <.001 | – | – |
| GCS min | 1.13 (1.10–1.15) | <.001 | 1.08 (1.06–1.11) | <.001 |
| SAPS II | 0.97 (0.97–0.98) | <.001 | – | – |
| SOFA > 4 | 0.42 (0.34–0.52) | <.001 | – | – |
| HR mean 24 h | 0.99 (0.98–0.99) | <.001 | – | – |
| SBP min <90 | 0.73 (0.62–0.86) | <.001 | – | – |
| MAP min 24 h | 1.01 (1.00–1.01) | .006 | – | – |
| T mean 24 h | 0.98 (0.85–1.13) | 0.77 | – | – |
| SPO2 first mean | 1.03 (1.01–1.04) | <.001 | – | – |
| Urine volume 24 h | 1.00 (1.00–1.01) | .008 | – | – |
| Urine volume to weight ratio 24 h | 1.64 (1.32–2.06) | <.001 | 1.39 (1.10–1.78) | .007 |
| Post-AKI urine volume max 24 h | 1.00 (1.00–1.01) | <.001 | – | – |
| Post-AKI urine volume min 24 h | 1.00 (1.00–1.01) | <.001 | – | – |
| Baseline SCr | 1.08 (1.06–1.10) | <.001 | – | – |
| SCr min 12 h | 0.40 (0.34–0.48) | <.001 | – | – |
| SCr min 24 h | 0.29 (0.24–0.36) | <.001 | – | – |
| Post-AKI SCr min 24 h | 0.57 (0.40–0.79) | .001 | – | – |
| Post-AKI SCr max 24 h | 0.34 (0.29–0.39) | <.001 | 0.54 (0.45–0.63) | <.001 |
| Hemoglobin min 24 h | 1.11 (1.07–1.15) | <.001 | – | – |
| Leucocyte max 24 h | 0.98 (0.97–0.99) | <.001 | – | – |
| Platelet min 24 h | 1.00 (1.00–1.01) | .001 | – | – |
| Basophils min 24 h | 0.97 (0.95-0.99) | .029 | – | – |
| Monocyte max 24 h | 1.00 (0.99–1.00) | .120 | – | – |
| Albumin <3.5 | 0.63 (0.53–0.74) | <.001 | – | – |
| BUN max 24 h | 0.97 (0.96–0.98) | <.001 | 0.99 (0.98–1.00) | .007 |
| Lactate max 24 h | 0.82 (0.79–0.85) | <.001 | 0.92 (0.88–0.97) | .001 |
| Anion Gap min 24 h | 0.92 (0.90–0.94) | <.001 | 0.95 (0.92–0.98) | .002 |
| Base excess min 24 h | 1.07 (1.05–1.09) | <.001 | – | – |
| Prothrombin time min 24 h | 0.98 (0.98–0.99) | .001 | 0.99 (0.98–1.00) | .068 |
| Sodium min 24 h | 1.02 (1.00–1.03) | .030 | – | – |
| Chloride min 24 h | 1.01 (0.99–1.02) | .150 | – | – |
| Bicarbonate max 24 h | 1.07 (1.05–1.09) | <.001 | – | – |
| Vancomycin | 0.35 (0.28–0.42) | <.001 | 0.58 (0.47–0.73) | <.001 |
| Antibiotic duration | 0.37 (0.28–0.48) | <.001 | – | – |
| Nephrotoxic drug | 0.31 (0.23–0.42) | <.001 | – | – |
| Vasopressin | 0.28 (0.22–0.36) | <.001 | 0.68 (0.51–0.91) | .009 |
| Phenylephrine | 0.56 (0.48–0.67) | <.001 | 0.68 (0.51–0.91) | .009 |
| Epinephrine | 0.42(0.32–0.55) | <.001 | 0.81 (0.58–1.14) | .226 |
| Furosemide | 0.34 (0.27–0.42) | <.001 | 0.57 (0.45–0.72) | <.001 |
| Post-AKI ventilation 24 h | 1.48 (1.26–1.74) | <.001 | 1.44 (1.20–1.73) | <.001 |
| AKI Stage | 1.29 (1.09–1.54) | .030 | – | – |
AKI: acute kidney disease; BUN: blood urea nitrogen; HR: heart rate; MAP: mean arterial pressure; RRT: renal replacement therapy; SAPS II: Simplified Acute Physiology score II; SBP: systolic pressure; SCr: serum creatinine; SOFA score: Sepsis-Related Organ Failure Assessment Score; SPO2: peripheral oxygen saturation; T: temperature.