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. Author manuscript; available in PMC: 2022 Aug 9.
Published in final edited form as: Biol Psychiatry. 2020 Jul 1;89(5):497–509. doi: 10.1016/j.biopsych.2020.06.021

Figure 1.

Figure 1.

Generation and characterization of CNV lines. (A) Information on donors of fibroblasts, including age, sex, and genotype. (B) Induced neuron generation timeline. (C) Sequencing read depth of fibroblast samples. (D) Immunocytochemistry for the pluripotency markers Nanog, TRA-1–60, and SSEA-4 on iPSCs (scale bar = 200 μm). (E) Immunocytochemistry for the neuronal markers MAP2, VGLUT1, and TUJ1 on day 6–induced neurons (scale bar = 200 μm). (F) Top 10 GO biological process terms from gene set enrichment analysis of genes differentially expressed between iPSCs and iNs, ordered by NES. Chr, chromosome; CNV, copy number variant; GO, Gene Ontology; iN, induced neuron; iPSC, induced pluripotent stem cell; NES, normalized enrichment score.