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. 2022 May 13;21(17):1842–1855. doi: 10.1080/15384101.2022.2074199

Figure 1.

Figure 1.

NUSAP1 expression is up-regulated in high grade gliomas and inversely associated with glioblastoma patient prognosis. A. Relative expression levels of NUSAP1 mRNA in normal brain (NBT), low grade glioma (LGG) and high grade glioma tissue samples from the CGGA, TCGA and rembrandt databases. **P < 0.01 and ***P < 0 .001. B. Kaplan-Meier analyses showing differences in overall survival for patients with low and high NUSAP1 expressing gliomas from CGGA, TCGA and rembrandt databases. C. Representative images of immunohistochemical staining for NUSAP1 in 4-μm sections from normal brain tissue samples (NBT), and grade II, III and IV (GBM) gliomas. Scale bar = 100 μm. D. Immunohistochemical scores for NUSAP1 in normal brain tissue samples (NBT), and grade II, III, and IV (GBM) gliomas. Five random fields from each section were counted. Data are shown as the mean ± SD. *P < 0.05, **P < 0 .01 and ***P < 0.001. E. Western blot analysis of NUSAP1 levels in grade II, III and IV gliomas. F. Western blot analysis of NUSAP1 levels in U87, A172, U251,T98 and GBM patient derived P3 cell lines.