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. 2022 May 13;21(17):1842–1855. doi: 10.1080/15384101.2022.2074199

Figure 5.

Figure 5.

Down-regulation of NUSAP1 inhibits the expression of TOP2A, and leads to reduced glioma growth and invasion in vivo. A. U251 cells expressing luciferase were orthotopically implanted into athymic nude mice. Tumor growth was monitored using the IVIS-200 imaging system for detection of bioluminescence. Bioluminescent signals were measured at days 7, 14, 21, and 28 after implantation. B. Kaplan-Meier survival analysis of overall survival, and log rank analysis to assess the statistical significance of the differences. C. Representative images of H&E staining and immunohistochemical staining for NUSAP1, MKI67, and TOP2A in xenograft sections from mice injected with U251- and P3-shNC or U251- and P3-shNUSAP1 cells. Scale bar = 100 μm. D. Graphic representation of IHC scoring for NUSAP1, MKI67, and TOP2A expression in xenograft sections. All data are presented as the mean ± SD, **P < 0.01.