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In vivo efficacy evaluation of saline, free exosome, free doxorubicin and exosome-doxorubicin through intravenous injection in MG63 xenograft tumor-bearing nude mice. Images of tumor-bearing mice (A) and the xenograft tumor (B). Tumor volume changes (C) as well as the weight of the excised tumor tissues (D) from all groups. Mean ± SD, n = 5. ns, not significant. **p < 0.01, ***p < 0.001, ****p < 0.0001 when compared with the indicated groups.
