Table 1.
Physicochemical properties of some antiviral drugs.
| Virus | Antiviral drug | Trade name | Formula | Molecular weight (MW) (g/mol) | Log Kow | pKa (acidic, basic) |
Bioavailability |
|---|---|---|---|---|---|---|---|
| HIV | Abacavir | Ziagen | C14H18N6O | 286.33 | 1.2 | 15.41, 5.8 | 1 |
| Zidovudine | Retrovir | C10H13N5O4 | 267.24 | 0.05 | 9.96, −3 | 1 | |
| Lamivudine | Epivir | C8H11N3O3S | 229.26 | −9.54 | 14.29, −0.16 | 1 | |
| Stavudine | Zerit | C10H12N2O4 | 224.21 | −0.72a | 9.95, −3 | 1 | |
| Nevirapine | Viramune | C15H12N2O4 | 266.29 | 3.89 | 14.98, 3.28 | 1 | |
| HSVs | Acyclovir | Zovirax | C8H11N5O3 | 225.20 | −1.56 | 11.98, 3.02 | 1 |
| Famciclovir | Famvir | C14H19N5O4 | 321.33 | 0.64 | 16.68, 3.65 | 1 | |
| Penciclovir | Denavir | C10H15N5O3 | 253.25 | −1.14 | 12, 2.88 | 1 | |
| Influenza | Amantadine | Gocovri | C10H17N | 151.24 | 2.44 | -, 10.71 | 1 |
| Oseltamivir | Tamiflu | C16H28N2O4 | 312.4 | 0.95 | 14.03, 9.31 | 1 | |
| Zanamivir | Relenza | C12H20N4O7 | 332.3 | −4.66 | 3.06, 11.93 | 0 | |
| SARS-CoV-2 | Favipiravir | Favipiravir | C5H4FN3O2 | 157.1 | – | 9.39, −3.7 | 1 |
| Remdesivir | Veklury | C27H35N6O8P | 602.58 | – | 10.23, 0.65 | 0 |
a
at 37 °C.