Table I.
Baseline characteristics
| Demographic characteristic | Immediate hypersensitivity reactions |
Immunization stress-related responses |
||||
|---|---|---|---|---|---|---|
| Cases 1 (N = 306) | Controls 1 (N = 1224) | P value∗ | Cases 2 (N = 2478) | Controls 2 (N = 9912) | P value† | |
| Age (y) | ||||||
| >65 | 108 (35) | 467 (38) | .817 | 430 (20) | 2344 (26) | <.001 |
| 51-65 | 69 (23) | 258 (21) | 361 (13) | 1913 (18) | ||
| 36-50 | 68 (22) | 264 (22) | 620 (26) | 2815 (29) | ||
| ≤35 | 61 (20) | 235 (19) | 1067 (41) | 2840 (27) | ||
| Sex | ||||||
| Male | 63 (21) | 692 (57) | <.001 | 827 (33) | 5475 (55) | <.001 |
| Female | 243 (79) | 532 (44) | 1651 (67) | 4437 (45) | ||
| Comorbidities | ||||||
| Hypertension | 40 (13) | 156 (13) | .848 | 163 (7) | 899 (9) | <.001 |
| Dyslipidemia | 17 (6) | 58 (5) | .552 | 89 (4) | 406 (4) | .303 |
| Diabetes | 12 (4) | 59 (5) | .647 | 55 (2) | 351 (4) | .002 |
| Cardiovascular diseases | 5 (2) | 40 (3) | .182 | 57 (2) | 197 (2) | .284 |
| Asthma | 24 (8) | 17 (1) | <.001 | 96 (4) | 123 (1) | <.001 |
| Atopic dermatitis | 5 (2) | 3 (0) | .010 | 21 (1) | 36 (0) | .002 |
| Thyroid diseases | 15 (5) | 13 (1) | <.001 | 50 (2) | 89 (1) | <.001 |
| Malignancy | 6 (2) | 21 (2) | .807 | 26 (1) | 90 (1) | .476 |
| Mental disorders | 7 (2) | 20 (2) | .463 | 113 (5) | 127 (1) | <.001 |
| Missing data of comorbidities | 4 (1) | 0 | 33 (1) | 0 | ||
| History | ||||||
| Allergic episodes for drugs | 86 (28) | 41 (3) | <.001 | 320 (13) | 303 (3) | <.001 |
| Allergic episodes for foods | 80 (26) | 33 (3) | <.001 | 308 (12) | 327 (3) | <.001 |
| Vasovagal episode | 9 (3) | 10 (1) | .006 | 246 (10) | 136 (1) | <.001 |
| Missing data of histories | 6 (2) | 0 | 45 (2) | 10 (0) | ||
| No. of vaccine received | ||||||
| First | 207 (68) | 828 (68) | 1.000 | 1844 (74) | 7376 (74) | 1.000 |
| Second | 99 (32) | 396 (32) | 634 (26) | 2536 (26) | ||
| Period | ||||||
| May 24-June 23 | 98 (32) | 392 (32) | 1.000 | 486 (20) | 1944 (20) | 1.000 |
| June 24-July 23 | 58 (19) | 232 (19) | 323 (13) | 1292 (13) | ||
| July 24-August 23 | 89 (29) | 356 (29) | 1071 (43) | 4284 (43) | ||
| August 24-September 24 | 61 (19) | 244 (20) | 598 (24) | 2392 (24) | ||
Data are presented as n (%).
∗
P value showed a comparison between cases 1 and control 1.
†
P value showed a comparison between cases 2 and control 2.