Table 1.
Derivation, development, replication, and coronavirus disease 2019 (COVID-19) datasets.
| Outcome | Gestational age (weeks) |
Total | |||
|---|---|---|---|---|---|
| <16 | 16 ∼ 23 | 24 ∼ 31 | 32 ∼ 40 | ||
| Surrogate transcriptome model | |||||
| GSE73685 (pairwise samples) – derivation dataset | 136 | ||||
| Fundus myometrium vs maternal blood | 19 | ||||
| Decidua (maternal side) vs maternal blood | 21 | ||||
| Placenta (fetal side) vs maternal blood | 14 | ||||
| Amnion (inner) vs maternal blood | 20 | ||||
| Chorion (outer) vs maternal blood | 20 | ||||
| Cord (fetal) blood vs maternal blood | 18 | ||||
| Lower-segment myometrium vs maternal blood | 22 | ||||
| Excluded (technical outliers) | 2 | ||||
| Prediction model | |||||
| GSE108497 – development dataset (no intervention) | 512 | ||||
| Normal (nonevent) | 75 | 69 | 73 | 68 | 285 |
| Isolated fetal growth restriction (small gestational age) (nonevent) | 6 | 7 | 5 | 3 | 21 |
| Early-onset preeclampsia (event) | 8 | 8 | 6 | 0 | 22 |
| Late-onset preeclampsia (event) | 4 | 3 | 3 | 3 | 13 |
| Excluded (technical outliers; outcome with extremely underrepresented gestational age, i.e., n = 1) | 171 | ||||
| GSE85307 – replication dataset (vitamin D +/-) | 157 | ||||
| Normal (nonevent) | 64 | 44 | 0 | 0 | 108 |
| Early-onset preeclampsia (event) | 28 | 13 | 0 | 0 | 41 |
| Late-onset preeclampsia (event) | 4 | 2 | 0 | 0 | 6 |
| Excluded (technical outliers) | 2 | ||||
| GSE86200 – replication dataset (vitamin D +/-) | 60 | ||||
| Normal (nonevent) | 17 | 7 | 0 | 24 | 48 |
| Preeclampsia (event) | 5 | 1 | 0 | 6 | 12 |
| Excluded (technical outliers) | 1 | ||||
| GSE149437 – replication dataset (no intervention) | 442 | ||||
| Normal (nonevent) | 0 | 0 | 0 | 20 | 20 |
| Spontaneous preterm delivery (nonevent) | 25 | 45 | 62 | 30 | 162 |
| Preterm premature rupture of membranes (nonevent) | 26 | 52 | 73 | 36 | 187 |
| Early-onset preeclampsia (event) | 11 | 23 | 23 | 9 | 66 |
| Excluded (technical outliers) | 7 | ||||
| GSE177477 – COVID-19 dataset | 47 | ||||
| Uninfected controls (nonevent) | 18 | ||||
| Asymptomatic cases (event) | 18 | ||||
| Mild cases (event) | 3 | ||||
| Severe cases (event) | 8 | ||||
| Excluded (technical outliers) | 0 | ||||