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Mechanisms of NMDAR modulation by adrenergic receptors.
α2ARs inhibit NMDAR function via negative-regulation of the AC/cAMP/PKA pathway. α2AR inhibitory effect on NMDAR function relies on the interaction with RGS4. βARs enhance NMDAR function by positively modulating the cAMP/PKA pathway. Activation of α1ARs triggers a PLC/IP3/calcium-dependent depression of NMDAR transmission. The inhibitory effect of α1ARs relies on the interaction with RGS2/4 and the scaffold protein spinophilin.
