TABLE 2.
Genotype distribution, allele frequency, and genetic models of the six VDR genetic variations between OM patients and healthy controls.
| SNP | Item | Patients | Controls | p values | OR (95%CI) | |
|---|---|---|---|---|---|---|
| ApaI rs7975232 | Genotype (n, %) | AA | 29 (7.3) | 43 (11.7) | 0.102 | |
| AC | 173 (43.5) | 158 (42.9) | ||||
| CC | 196 (49.2) | 167 (45.4) | ||||
| Allele frequency | A vs. C | 231/565 | 244/492 | 0.081 | 0.824 (0.664–1.024) | |
| Dominant model | AA + AC vs. CC | 202/196 | 201/167 | 0.284 | 0.856 (0.644–1.138) | |
| Recessive model | AA vs. AC + CC | 29/369 | 43/325 | 0.037 | 0.594 (0.362–0.973) | |
| Homozygous model | AA vs. CC | 29/196 | 43/167 | 0.033 | 0.575 (0.344–0.961) | |
| Heterzygous model | AC vs. CC | 173/196 | 158/167 | 0.649 | 0.933 (0.692–1.257) | |
| BsmI rs1544410 | Genotype (n, %) | TT | 1 (0.3) | 1 (0.3) | 0.144 | |
| CT | 29 (7.3) | 42 (11.4) | ||||
| CC | 368 (92.4) | 325 (88.3) | ||||
| Allele frequency | T vs. C | 31/765 | 44/692 | 0.059 | 0.637 (0.398–1.021) | |
| Dominant model | TT + CT vs. CC | 30/368 | 43/325 | 0.051 | 0.616 (0.378–1.005) | |
| Recessive model | TT vs. CT + CC | 1/397 | 1/367 | 0.956 | 0.924 (0.058–14.833) | |
| Homozygous model | TT vs. CC | 1/368 | 1/325 | 1.000 | 0.883 (0.055–14.176) | |
| Heterzygous model | CT vs. CC | 29/368 | 42/325 | 0.049 | 0.610 (0.371–1.002) | |
| FokI rs2228570 | Genotype (n, %) | GG | 104 (26.1) | 103 (28.0) | 0.154 | |
| AG | 200 (50.3) | 199 (54.1) | ||||
| AA | 94 (23.6) | 66 (17.9) | ||||
| Allele frequency | G vs. A | 408/388 | 405/331 | 0.140 | 0.859 (0.703–1.051) | |
| Dominant model | GG + AG vs. AA | 304/94 | 302/66 | 0.053 | 0.707 (0.497–1.006) | |
| Recessive model | GG vs. AG + AA | 104/294 | 103/265 | 0.563 | 0.910 (0.662–1.252) | |
| Homozygous model | GG vs. AA | 104/94 | 103/66 | 0.105 | 0.709 (0.468–1.075) | |
| Heterzygous model | AG vs. AA | 200/94 | 199/66 | 0.065 | 0.706 (0.487–1.023) | |
| TaqI rs731236 | Genotype (n, %) | GG | 0 (0.0) | 2 (0.5) | 0.23 | |
| AG | 28 (7.0) | 32 (8.7) | ||||
| AA | 370 (93.0) | 334 (90.8) | ||||
| Allele frequency | G vs. A | 28/768 | 36/700 | 0.179 | 0.709 (0.428–1.174) | |
| Dominant model | GG + AG vs. AA | 28/370 | 34/334 | 0.264 | 0.743 (0.441–1.252) | |
| Recessive model | GG vs. AG + AA | 0/398 | 2/366 | 0.230 | 1.005 (0.998–1.013) | |
| Homozygous model | GG vs. AA | 0/370 | 2/334 | 0.226 | 1.006 (0.998–1.014) | |
| Heterzygous model | AG vs. AA | 28/370 | 32/334 | 0.381 | 0.790 (0.466–1.340) | |
| GATA rs4516035 | Genotype (n, %) | CC | 0 (0.0) | 0 (0.0) | 0.168 | |
| CT | 29 (7.3) | 18 (4.9) | ||||
| TT | 369 (92.7) | 350 (95.1) | ||||
| Allele frequency | C vs. T | 29/767 | 18/718 | 0.174 | 1.508 (0.830–2.739) | |
| Dominant model | CC + CT vs. TT | 29/369 | 18/350 | 0.168 | 1.528 (0.834–2.801) | |
| Recessive model | CC vs. CT + TT | 0/398 | 0/368 | N/A | N/A | |
| Homozygous model | CC vs. TT | 0/369 | 0/350 | N/A | N/A | |
| Heterzygous model | CT vs. TT | 29/369 | 18/350 | 0.168 | 1.528 (0.834–2.801) | |
| Cdx-2 rs11568820 | Genotype (n, %) | TT | 71 (17.8) | 69 (18.8) | 0.641 | |
| CT | 193 (48.5) | 166 (45.1) | ||||
| CC | 134 (33.7) | 133 (36.1) | ||||
| Allele frequency | T vs. C | 335/461 | 304/432 | 0.757 | 1.033 (0.843–1.265) | |
| Dominant model | TT + CT vs. CC | 264/134 | 235/133 | 0.473 | 1.115 (0.828–1.501) | |
| Recessive model | TT vs. CT + CC | 71/327 | 69/299 | 0.745 | 0.941 (0.652–1.357) | |
| Homozygous model | TT vs. CC | 71/134 | 69/133 | 0.920 | 1.021 (0.678–1.537) | |
| Heterzygous model | CT vs. CC | 193/134 | 166/133 | 0.376 | 1.154 (0.840–1.585) |
Bold values represent statistical signicance. OM, osteomyelitis; OR, odds ratio; CI, confidence interval; N/A, not available.