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(a) Principle of conventional cancer vaccine by systemically injecting tumor antigens vs in situ cancer vaccine by intratumorally injecting immunoadjuvants to stimulate tumor antigen release. (b) Schematic showing nMOF-mediated local treatment, including PDT, RT, RT-RDT, and CDT, to kill tumor cells via ROS generation and augment innate immunity for synergistic effects with CBI.
