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. Author manuscript; available in PMC: 2022 Aug 9.
Published in final edited form as: Acc Chem Res. 2020 Aug 18;53(9):1739–1748. doi: 10.1021/acs.accounts.0c00313

Figure 6.

Figure 6.

(a) Schematic showing Hf-DBP -enabled RT-RDT to generate both •OH via radiolysis and 1O2 via energy transfer to DBP. (b) in vitro DNA double strand breaks and 1O2 generation probed by γ-H2AX and SOSG, respectively. Scale bar = 10 μm. (c) Schematic illustration of abscopal effect induced by nMOF-enabled RT-RDT and IDOi. Tumor growth curves of treated primary (right, d) and untreated distant (left, e) tumors after treatment with Hf-DBP plus X-ray irradiation. (f) Tumor curves after treatment with Hf-DBP-mediated RT-RDT with depletion of B cell or T cell. (g) Plasma kynurenine concentrations of mice intratumorally injected with IDOi@ Hf-DBP-. N=3. Black, red and blue arrows refer to intratumoral injection, X-ray irradiation and intraperitoneal injection, respectively. Reproduced with permission from Ref. 3. Copyright 2018 Nature Publishing Group.