TABLE 1.
Characteristics of MIS-C and Acute COVID Cases in 16-county Area for University of Mississippi Medical Center, March 2020 Through February 2021
| MIS-C* (N = 38), No. (%) | Acute COVID-19 Hospitalizations* (N = 74), No. (%) | |
|---|---|---|
| Age group (yrs) | ||
| <1 | 0 (0) | 21 (28) |
| 1–5 | 12 (32) | 10 (14) |
| 6–10 | 11 (29) | 8 (11) |
| 11–17 | 15 (39) | 35 (47) |
| Race/ethnicity † | ||
| Hispanic | 0 (0) | 5 (7) |
| Non-Hispanic | ||
| Black | 31 (82) | 49 (66) |
| Other‖ | 2 (5) | 4 (5) |
| White | 4 (11) | 16 (22) |
| Sex | ||
| Female | 21 (55) | 27 (36) |
| Male | 17 (45) | 47 (64) |
| Month ‡ | ||
| Apr 2020 | 1 (3) | 4 (5) |
| May 2020 | 1 (3) | 6 (8) |
| Jun 2020 | 1 (3) | 5 (7) |
| Jul 2020 | 1 (3) | 11 (15) |
| Aug 2020 | 3 (8) | 4 (5) |
| Sep 2020 | 5 (13) | 2 (3) |
| Oct 2020 | 0 (0) | 2 (3) |
| Nov 2020 | 0 (0) | 11 (15) |
| Dec 2020 | 5 (13) | 12 (16) |
| Jan 2021 | 12 (32) | 12 (16) |
| Feb 2021 | 9 (24) | 5 (7) |
| Underlying medical condition | ||
| ≥1 underlying medical condition‡ | 13 (34) | 43 (58) |
| Chronic lung disease | 4 (11) | 18 (24) |
| Chronic metabolic disease | 2 (5) | 8 (11) |
| Sickle cell disease | 1 (3) | 6 (8) |
| Cardiovascular disease | 3 (8) | 5 (7) |
| Neurologic disorder | 3 (8) | 10 (14) |
| Immunocompromised condition | 0 (0) | 3 (4) |
| Gastrointestinal/liver disease | 0 (0) | 9 (12) |
| Renal disease | 1 (3) | 3 (4) |
| Prematurity | 1 (3) | 3 (4) |
| Other¶ | 0 (0) | 4 (5) |
| Obesity § | 15 (42) | 21 (42) |
| ICU stay | ||
| Admitted to ICU | 19 (50) | 21 (28) |
| Length of stay, median (IQR), d | 8.0 (5.9–9.8) | 4.8 (2.7–9.8) |
BMI indicates body mass index; IQR, interquartile range; MIS-C, multisystem inflammatory syndrome in children.
One participant contributed to both MIS-C and acute COVID-19 hospitalization frequencies, and age groups above were chosen to match Supplementary Table 1 and Mississippi State Department of Health age group for Pediatric COVID-19/MIS-C reporting (https://msdh.ms.gov/msdhsite/_static/14,0,420,873.html#pediatric). By CDC age groups, our frequencies are as follows: age < 1, 0/38 or 0%; age 1–4, 9/38 (24%); age 5–11, 15/38 (39%); age 12–15, 8/38 (21%); age 16 to <18, 6/38 (16%).
Ethnicity for 1 MIS-C case who identifies as Black is missing.
No cases in March.
Obesity defined as BMI equal to or greater than the 95th percentile in age- and sex-specific groups. BMI not calculated for children <2 years—therefore percent expressed accounts for 36 MIS-C (2 were under age 2) and 50 (24 were under age 2) for acute COVID-19 hospitalized children, respectively.
Other includes rheumatologic, autoimmune, and inflammatory conditions.
‖Conditions were categorized using Epic data for encounter diagnoses and problem lists as previously published with the following notations: includes asthma but not wheezing without asthma diagnosis; new onset diabetes mellitus with COVID requiring hospitalization was included (not chronic metabolic); new onset heart murmurs were not categorized as chronic cardiovascular disease unless associated with a diagnosis of abnormality by echocardiogram; hemoglobinopathy included sickle cell disease; malignancy was categorized under “immunocompromised.”