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. 2021 Dec 13;82(4):695–707. doi: 10.1158/0008-5472.CAN-20-3209

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©2021 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 3. HDAC2 controls a route to metastasis in vivo. A, Kaplan–Meier plots of KPC (black), KPCH2lox/+(red), and KPCH2lox/lox (blue) mice. B, Hematoxylin and eosin staining of murine PDAC from KPC and KPCH2lox/lox mice. G1, well-differentiated; G2, moderately differentiated; G3, poorly differentiated; G4, undifferentiated PDAC. Scale bar, 500 μm. C and D, Quantification of Ki67 stainings (C) and cleaved caspase-3 (D) stainings in murine PDAC from KPC (n = 4) and KPCH2lox/lox (n = 5) mice. E, Quantification of gradings from KPC and KPCH2lox/lox mice. F, Morphology of murine PDAC cell lines from KPC (n = 8) and KPCH2lox/lox mice (n = 7) was evaluated and stratified as epithelial (epi; blue), mesenchymal (mes; red), or as intermediate/mixed (mixed; green). G, Metastasis frequency of KPC and KPCH2lox/lox mice. **, P < 0.01 (Fisher exact test). H, Hematoxylin and eosin staining of liver and lung metastasis of KPC and KPCH2lox/lox mice. Scale bar, 500 μm. I, HDAC2 IHC of liver and lung metastasis of KPCH2lox/lox mice. Scale bar, 200 μm. — HDAC2 controls a route to metastasis in vivo. A, Kaplan–Meier plots of KPC (black), KPCH2^lox/+(red), and KPCH2^lox/lox (blue) mice. B, Hematoxylin and eosin staining of murine PDAC from KPC and KPCH2^lox/lox mice. G1, well-differentiated; G2, moderately differentiated; G3, poorly differentiated; G4, undifferentiated PDAC. Scale bar, 500 μm. C and D, Quantification of Ki67 stainings (C) and cleaved caspase-3 (D) stainings in murine PDAC from KPC (n = 4) and KPCH2^lox/lox (n = 5) mice. E, Quantification of gradings from KPC and KPCH2^lox/lox mice. F, Morphology of murine PDAC cell lines from KPC (n = 8) and KPCH2^lox/lox mice (n = 7) was evaluated and stratified as epithelial (epi; blue), mesenchymal (mes; red), or as intermediate/mixed (mixed; green). G, Metastasis frequency of KPC and KPCH2^lox/lox mice. **, P < 0.01 (Fisher exact test). H, Hematoxylin and eosin staining of liver and lung metastasis of KPC and KPCH2^lox/lox mice. Scale bar, 500 μm. I, HDAC2 IHC of liver and lung metastasis of KPCH2^lox/lox mice. Scale bar, 200 μm.