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. 2022 Mar 15;82(6):1013–1024. doi: 10.1158/0008-5472.CAN-21-1707

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 7. Combined inhibition of CTPS1 and ATR induces synthetic lethality in MYC-overexpressing cells. MYC-overexpressing cells are dependent on CTPS1 for DNA replication and rRNA synthesis. Inhibiting CTPS1 induces replication stress and consequent apoptosis when combined with ATR inhibitor in MYC-overexpressing cells. — Combined inhibition of CTPS1 and ATR induces synthetic lethality in MYC-overexpressing cells. MYC-overexpressing cells are dependent on CTPS1 for DNA replication and rRNA synthesis. Inhibiting CTPS1 induces replication stress and consequent apoptosis when combined with ATR inhibitor in MYC-overexpressing cells.