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. 2022 Jul 29;14(8):884–890. doi: 10.1038/s41557-022-01005-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — Left panel: stereoselectivity of the asymmetric dihydroxylation (AD)-mix β leads to mainly S-configurated products²⁰; Bn: benzyl protecting group. Consequently AD-mix α forms mainly R-configurated products. Chiral HR-LCMS (bottom left) validates the successful asymmetric synthesis with AD-mix α after hydrolysis of the formed ethyl ester (Et). Right panel: chiral HR-LCMS of asymmetric synthesis products (ref.) vs. enzymatically formed 6 shows the stereochemistry of enzymatically formed 6 to be of R-configuration.

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